Our regular Vet, who is a close friend of ours as well, is not available for the next ten days as he had emergency surgery. Prior to his emergency, we got the unfortunate news that Max, our mini Schnauzer, 14 yrs young, looks like he is in early stages of kidney failure. That was three weeks ago. We had to wait about ten days for his supplments, Azodyl, Epakitin, B-12 Vitamins...plus we continued with our low phosphorous home made diet. He also prescribed ACE enalapril, of which I didn't give him for about five days as I was really nervous about him going into "kidney failure" with this drug. It is 1.25, and he suggested it for the protein loss, and said it won't affect his kidneys. Well, after much thought and angst, I went against my gut instinct and put him on it. He became very lethargic, almost like a different dog. I felt it was from the drug. So, I couldn't reach our vet, and took him off of it after four days. By the third day of being off of this drug, and continuing on the supplements. He became alert, playful almost like before, but not quite. And, he even ran on our back porch. He was eating with vigor. Then my Vet contacted us to see how he was doing, and said, it's your call with the ACE inhibitor, but if it were my dog I'd put him on it. He suggested I try it again and if adverse reaction again, then stop it. Well, again against my gut, put him on it, and past two days, totally out of it...sleeping and walking so slowly. Do you think it's this drug? And, is this drug really necessary in the regime to try and slow the progression, of which we know it will get worse eventually. We just want him to be happy, and not drugged up. Oh, and also on Renal Vitamins and Pepcid 2x day. Can a dog stay at early stages for awhile before progessing? Has that ever happened? Also, it was discovered he had a very new and small heart murmur last time he was checked. He is on thyroid meds for about 7 years...and he is 20 pounds. Please let me know what you think...thanks. My husband and I are struggling with this news, and I've been personally obsessed with researching! Help! Thank you.